Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gfra1  glial cell line derived neurotrophic factor family receptor alpha 1   (Synonyms: GDNFR-alpha, GFR alpha-1)
Results	Reference
1	J:45374 Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM Jr, Milbrandt J, TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. 1997 May;18(5):793-802
1	J:64589 Baudet C, Mikaels A, Westphal H, Johansen J, Johansen TE, Ernfors P, Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins. Development. 2000 Oct;127(20):4335-44
1	J:340669 Choi JS, Ayupe AC, Beckedorff F, Catanuto P, McCartan R, Levay K, Park KK, Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly. Cell Rep. 2023 Aug 24;42(9):113037
1	J:114185 Enomoto H, Heuckeroth RO, Golden JP, Johnson EM, Milbrandt J, Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin. Development. 2000 Nov;127(22):4877-89
1	J:130616 Enomoto H, Hughes I, Golden J, Baloh RH, Yonemura S, Heuckeroth RO, Johnson EM Jr, Milbrandt J, GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron. 2004 Nov 18;44(4):623-36
1	J:220812 Fleming MS, Vysochan A, Paixao S, Niu J, Klein R, Savitt JM, Luo W, Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. Elife. 2015;4
1	J:54911 Fundin BT, Mikaels A, Westphal H, Ernfors P, A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation. Development. 1999 Jun;126(12):2597-610
1	J:56674 Golden JP, DeMaro JA, Osborne PA, Milbrandt J, Johnson EM Jr, Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Exp Neurol. 1999 Aug;158(2):504-28
1	J:210892 Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, Desvignes JP, Alonso S, Moqrich A, Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. PLoS Genet. 2014 Feb;10(2):e1004081
1	J:53261 Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A, Molliver DC, Bardgett ME, Snider WD, Johnson EM Jr, Milbrandt J, Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 1999 Feb;22(2):253-63
1	J:83661 Holm PC, Rodriguez FJ, Kresse A, Canals JM, Silos-Santiago I, Arenas E, Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Development. 2003 Aug;130(15):3535-45
1	J:108404 Lindfors PH, Lindahl M, Rossi J, Saarma M, Airaksinen MS, Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Endocrinology. 2006 May;147(5):2237-44
1	J:157722 Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD, Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron. 2009 Dec 24;64(6):841-56
1*	J:126484 Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD, A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
1	J:44407 Luukko K, Suvanto P, Saarma M, Thesleff I, Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis. Dev Dyn. 1997 Dec;210(4):463-71
1	J:193051 Marks C, Belluscio L, Ibanez CF, Critical role of GFRalpha1 in the development and function of the main olfactory system. J Neurosci. 2012 Nov 28;32(48):17306-20
1	J:335232 McCoy ME, Kamitakahara AK, Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types. eNeuro. 2023 Apr;10(4):ENEURO.0511-22.2023
1	J:63340 Mikaels A, Livet J, Westphal H, De Lapeyriere O, Ernfors P, A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development. Eur J Neurosci. 2000 Feb;12(2):446-56
1	J:43790 Molliver DC, Wright DE, Leitner ML, Parsadanian AS, Doster K, Wen D, Yan Q, Snider WD, IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
1*	J:45661 Naveilhan P, Baudet C, Mikaels A, Shen L, Westphal H, Ernfors P, Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1295-300
1	J:57342 Nishino J, Mochida K, Ohfuji Y, Shimazaki T, Meno C, Ohishi S, Matsuda Y, Fujii H, Saijoh Y, Hamada H, GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion. Neuron. 1999 Aug;23(4):725-36
1	J:44374 Nosrat CA, Tomac A, Hoffer BJ, Olson L, Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. Exp Brain Res. 1997 Jul;115(3):410-22
1	J:336866 Puelles L, Hidalgo-Sanchez M, The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)
1	J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
1*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:147559 Thuret S, Alavian KN, Gassmann M, Lloyd CK, Smits SM, Smidt MP, Klein R, Dyck RH, Simon HH, The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem. 2004 Dec;91(6):1302-11
1	J:44582 Widenfalk J, Nosrat C, Tomac A, Westphal H, Hoffer B, Olson L, Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripherl organs. J Neurosci. 1997 Nov 1;17(21):8506-19
1	J:47085 Widenfalk J, Tomac A, Lindqvist E, Hoffer B, Olson L, GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells. Eur J Neurosci. 1998 Apr;10(4):1508-17